https://menalaboratory.org/home daily 1.0 2026-01-30 https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1618497259178-6XJGK9GR6YAVBQL5L519/20140301_Trade-151_012-2.jpg Home https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694583486-2PQT0LQ193RL7MCB6DX4/20140228_Trade+151_0046.jpg Home https://menalaboratory.org/contact daily 0.75 2026-03-27 https://images.squarespace-cdn.com/content/v1/69727cd80a0e8c16b6ffb265/ee03d34a-480b-4f62-ab33-4888d0344b17/lab_opening.jpg Join Us - Join Us! The Mena lab is open and actively recruiting! We welcome scientists from all backgrounds, and are intent on creating a welcoming, supportive environment. Interested technicians should email Elijah and include a CV/resume. Postdoctoral applicants should email Elijah with a CV and a brief statement describing past research and proposed future work. The Mena lab accepts graduate students through the UTSW basic sciences division. Students who are interested in rotating are encouraged to email Elijah directly. https://menalaboratory.org/people daily 0.75 2026-01-30 https://images.squarespace-cdn.com/content/v1/69727cd80a0e8c16b6ffb265/8a934755-04f9-4f54-a636-17f684fed1ce/microscope.jpg People https://images.squarespace-cdn.com/content/v1/69727cd80a0e8c16b6ffb265/1b63f46b-3153-4cf0-b09c-db6a5d3301ed/headshot_800_800.jpg https://menalaboratory.org/publications daily 0.75 2026-01-30 https://images.squarespace-cdn.com/content/v1/69727cd80a0e8c16b6ffb265/cd68aed6-3fc6-4f7b-9fa2-95c1e35c64d8/NRMCB_2025.png Publications Degrons: unraveling the lexicon of the ubiquitin-proteasome system Zhang Z, Mena EL, Timms RT, Koren I, Elledge S Nat Rev Mol Cell Biol (2025) https://images.squarespace-cdn.com/content/v1/69727cd80a0e8c16b6ffb265/3ba96c44-0aad-47c2-bc7a-1c4085c3d18b/multiplex_paper.png Publications Defining E3 ligase-substrate relationships through multiplex CRISPR screening Timms RT*, Mena EL*, Leng Y, Li MZ, Tchasovnikarova IA, Koren I, Elledge SJ Nature Cell Biol (2023) https://images.squarespace-cdn.com/content/v1/69727cd80a0e8c16b6ffb265/88547eb2-670b-439d-9670-90eb43d9d26b/FEM1B_structure.png Publications Structural basis and regulation of the reductive stress response Manford AG*, Mena EL*, Shih KY, Gee CL, McMinimy R, Martínez-González B, Sherriff R, Lew B, Zoltek M, Rodríguez-Pérez F, Woldesenbet M, Kuriyan J, Rape M Cell (2021) https://images.squarespace-cdn.com/content/v1/69727cd80a0e8c16b6ffb265/c54a4cb6-949e-4ce8-9a90-ba30f18fac4a/ZYG11B_PNAS_lowres.png Publications ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection Mena EL, Donahue CJ, Vaites LP, Li J, Rona G, O'Leary C, Lignitto L, Miwatani-Minter B, Paulo JA, Dhabaria A, Ueberheide B, Gygi SP, Pagano M, Harper JW, Davey RA, Elledge SJ Proc Natl Acad Sci U S A (2021) https://images.squarespace-cdn.com/content/v1/69727cd80a0e8c16b6ffb265/1d4e2347-6e1a-470d-bcea-049b3aa771c5/DQC_structure.png Publications Structural basis for dimerization quality control Mena EL, Jevtić P, Greber BJ, Gee CL, Lew BG, Akopian D, Nogales E, Kuriyan J, Rape M Nature (2020) https://images.squarespace-cdn.com/content/v1/69727cd80a0e8c16b6ffb265/9da988c8-4224-4ff8-ab47-e7c764176bed/Mena_DQC_discovery.png Publications Dimerization quality control ensures neuronal development and survival Mena EL, Kjolby RAS, Saxton RA, Werner A, Lew BG, Boyle JM, Harland R, Rape M Science (2018) https://menalaboratory.org/research daily 0.75 2026-01-30 https://images.squarespace-cdn.com/content/v1/69727cd80a0e8c16b6ffb265/298a16d9-f220-4a11-ac30-dd13892de6f2/Ub-Ind.png Research https://images.squarespace-cdn.com/content/v1/69727cd80a0e8c16b6ffb265/05ac47b3-ffff-4d38-bfda-315447ef5df7/screening.png Research https://images.squarespace-cdn.com/content/v1/69727cd80a0e8c16b6ffb265/1bc4595b-e3fe-4452-b980-d4b2a7ec9212/pathogenic_protein.png Research